Clinical and Experimental Otorhinolaryngology

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Review

July 6, 2018

Immunotherapy in Head and Neck Squamous Cell Cancer

Nerina Denaro, Marco Carlo Merlano

Clin Exp Otorhinolaryngol. 2018;11(4):217-223.

• Immunotherapy in head and neck squamous cell cancer represents a promising new opportunity of treatment.
• Unfortunately, only a small number of patients benefit from single approach/agent therapy (overall response rate remains around 20%).
• Combining immunotherapy and radiotherapy or biotherapy as well as reliable biomarkers for patients selection is expected to improve outcomes.

Original Article

October 13, 2018

The Presence of Neural Stem Cells and Changes in Stem Cell-Like Activity With Age in Mouse Spiral Ganglion Cells In Vivo and In Vitro

Byoung-San Moon, Aswathy Ammothumkandy, Naibo Zhang, Lei Peng, Albina Ibrayeva, Maxwell Bay, Athira Pratap, Hong Ju Park, Michael Anthony Bonaguidi, Wange Lu

Clin Exp Otorhinolaryngol. 2018;11(4):224-232.

• There were Nestin+/Ki67+spiral ganglion neurons (SGNs) even in 6-month-old mice.
• SGN spheres from young mice had more mitotic cells than those from old mice.
• SGNs have multipotent capacity of differentiating into neuron and glial cells.
• The number of neural stem cells (NSCs) in vivo decreased as a function of age.
• SGN-NSCs may serve as a source for the regeneration of SGNs even in old mice.

Original Article

June 27, 2018

Transcanal Endoscopic Ear Surgery for Congenital Cholesteatoma

Joo Hyun Park, Jungmin Ahn, Il Joon Moon

Clin Exp Otorhinolaryngol. 2018;11(4):233-241.

• Twenty-five children with congenital cholesteatoma (CC) confined to the middle ear underwent transcanal endoscopic ear surgery (TEES).
• CC was removed successfully in all patients and only one patient showed recurrence.
• Pediatric CC limited to the middle ear cavity can be safely and effectively removed using TEES.

Original Article

April 10, 2018

Urine Cotinine Should Be Involved in Initial Evaluation of Tinnitus in Adolescents

Doh Young Lee, Young Ho Kim

Clin Exp Otorhinolaryngol. 2018;11(4):242-249.

• This cross-sectional study involved 2,782 participants from the KNHANES data. Urine cotinine was an independent factor associated with tinnitus.
• Amount of smoking was also significantly associated with tinnitus-related annoyance.
• However, the history of current/past smoking was not correlated with tinnitus.

Original Article

June 19, 2018

Spoken and Written Narrative in Persian-Speaking Students Who Received Cochlear Implant and/or Hearing Aid

Peyman Zamani, Zahra Soleymani, Vahid Rashedi, Farhad Farahani, Gohar Lotf, Mohammad Rezaei

Clin Exp Otorhinolaryngol. 2018;11(4):250-258.

• The students with hearing impairments had lower scores in narrative skills than typical hearing peers.
• The cochlear implantation was more effective than hearing aid on spoken and written narrative skills.
• Hearing deprivation may limit microstructures of spoken/written narration in students who received cochlear implant or hearing aid relative to typical hearing peers.

Original Article

May 22, 2018

Prognostic Factors Affecting Surgical Outcomes in Squamous Cell Carcinoma of External Auditory Canal

Gi-Sung Nam, In Seok Moon, Ji Hyung Kim, Sung Huhn Kim, Jae Young Choi, Eun Jin Son

Clin Exp Otorhinolaryngol. 2018;11(4):259-266.

• Early tumor stage squamous cell carcinomas of the external auditory canal had good prognosis and lower rate of recurrence compared to advanced cases.
• Among the prognostic factors analyzed, advanced tumor stages and neck node recurrence were associated with poor treatment outcomes.
• Our results highlight the importance of early diagnosis and surgical treatment for squamous cell carcinomas of the external auditory canal.

Original Article

June 16, 2018

The Effects of Hearing Aid Digital Noise Reduction and Directionality on Acceptable Noise Level

Roghayeh Ahmadi, Hamid Jalilvand, Mohammad Ebrahim Mahdavi, Fatemeh Ahmadi, Ali Reza Akbarzade Baghban

Clin Exp Otorhinolaryngol. 2018;11(4):267-274.

• Among all conditions, both the omnidirectional-baseline condition and the omnidirectional-broadband digital noise reduction (DNR) condition are the worst conditions for listening in noise.
• The directionality (DIR) always reduces the amount of noise that patients received during testing.
• The DNR algorithm does not improve listening in noise significantly when compared with the DIR algorithms.
• Although it only reduces the amount of noise compared with the omnidirectional condition, the DNR must be set to the broadband condition rather than the multichannel condition.

Original Article

June 2, 2018

Triangular Resection of the Upper Lateral Cartilage for Middle Vault Deviation

Gwanghui Ryu, Min Young Seo, Kyung Eun Lee, Sang Duk Hong, Seung-Kyu Chung, Hun-Jong Dhong, Hyo Yeol Kim

Clin Exp Otorhinolaryngol. 2018;11(4):275-280.

• Triangular resection of the upper lateral cartilage is an additive surgical option for correcting middle vault deviation and it is a very simple and timesaving method.
• After removing surplus portion of the upper lateral cartilage, there was no influence on the dorsal width and no internal valve narrowing.

Original Article

May 16, 2018

Efficacy and Safety of Autologous Stromal Vascular Fraction in the Treatment of Empty Nose Syndrome

Do-Youn Kim, Hye Ran Hong, Eun Wook Choi, Sang Won Yoon, Yong Ju Jang

Clin Exp Otorhinolaryngol. 2018;11(4):281-287.

• The effect of autologous stromal vascular fraction injection was examined in nine patients with empty nose syndrome.
• The overall Sino-Nasal Outcome Test-25 score at 6 months after injection did not differ significantly from that of before the injection.
• The levels of interleukin (IL)-1β, IL-8, and calcitonin generelated peptide were significantly higher in empty nose syndrome patients.
• Nasal secretions from stromal vascular fraction-treated patients showed decreased expressions of IL-1β and IL-8 after injection.

Original Article

July 20, 2018

Common Sites, Etiology, and Solutions of Persistent Septal Deviation in Revision Septoplasty

Hong Ryul Jin, Dae Woo Kim, Hahn Jin Jung

Clin Exp Otorhinolaryngol. 2018;11(4):288-292.

• Septoplasty is one of the most commonly performed otolaryngologic procedures, but more than 15% of septoplasty patients fail to relieve their symptom.
• Incomplete separation and resection of bony-cartilaginous junction and inadequate correction of the caudal septal deviation are the main reasons for persistent septal deviation after primary septoplasty.
• It can be solved by proper chondrotomy with conservative excision of deviated septum, and correction of the caudal deviation with batten graft.

Original Article

July 20, 2018

Initial Nutritional Status and Clinical Outcomes in Patients with Deep Neck Infection

Marn Joon Park, Ji Won Kim, Yonghan Kim, Yoon Se Lee, Jong-Lyel Roh, Seung-Ho Choi, Sang Yoon Kim, Soon Yuhl Nam

Clin Exp Otorhinolaryngol. 2018;11(4):293-300.

• Risk factors of complicated deep neck infections were retrospectively examined in 135 patients.
• Initial serum albumin less than 3.0 g/dL was an independent serologic marker to predict complicated deep neck infection (P

Original Article

August 25, 2018

Body Surface Area Is Not a Reliable Predictor of Tracheal Tube Size in Children

Filiz Uzumcugil, Emre Can Celebioglu, Demet Basak Ozkaragoz, Aysun Ankay Yilbas, Basak Akca, Nazgol Lotfinagsh, Bilge Celebioglu

Clin Exp Otorhinolaryngol. 2018;11(4):301-308.

• The Cole formula, body surface area and ultrasonography had similar estimation rates in patients aged 24≤ to ≤96 months.
• Body surface area had a correct estimation rate of 40.2% and may not be reliable in clinical practice to predict uncuffed-endotracheal tube size.

Current Issue: Volume 11(4); Dec 2018

Immunotherapy in Head and Neck Squamous Cell Cancer Nerina Denaro, Marco Carlo Merlano Clin Exp Otorhinolaryngol. 2018;11(4):217-223. Review July 6, 2018 Full text PubReader ePub PDF	The Presence of Neural Stem Cells and Changes in Stem Cell-Like Activity With Age in Mouse Spiral Ganglion Cells In Vivo and In Vitro Byoung-San Moon, Aswathy Ammothumkandy, Naibo Zhang, Lei Peng, Albina Ibrayeva, Maxwell Bay, Athira Pratap, Hong Ju Park, Michael Anthony Bonaguidi, Wange Lu Clin Exp Otorhinolaryngol. 2018;11(4):224-232. Original Article October 13, 2018 Full text PubReader ePub PDF Supplementary Material
Transcanal Endoscopic Ear Surgery for Congenital Cholesteatoma Joo Hyun Park, Jungmin Ahn, Il Joon Moon Clin Exp Otorhinolaryngol. 2018;11(4):233-241. Original Article June 27, 2018 Full text PubReader ePub PDF	Urine Cotinine Should Be Involved in Initial Evaluation of Tinnitus in Adolescents Doh Young Lee, Young Ho Kim Clin Exp Otorhinolaryngol. 2018;11(4):242-249. Original Article April 10, 2018 Full text PubReader ePub PDF Supplementary Material
Spoken and Written Narrative in Persian-Speaking Students Who Received Cochlear Implant and/or Hearing Aid Peyman Zamani, Zahra Soleymani, Vahid Rashedi, Farhad Farahani, Gohar Lotf, Mohammad Rezaei Clin Exp Otorhinolaryngol. 2018;11(4):250-258. Original Article June 19, 2018 Full text PubReader ePub PDF	Prognostic Factors Affecting Surgical Outcomes in Squamous Cell Carcinoma of External Auditory Canal Gi-Sung Nam, In Seok Moon, Ji Hyung Kim, Sung Huhn Kim, Jae Young Choi, Eun Jin Son Clin Exp Otorhinolaryngol. 2018;11(4):259-266. Original Article May 22, 2018 Full text PubReader ePub PDF
The Effects of Hearing Aid Digital Noise Reduction and Directionality on Acceptable Noise Level Roghayeh Ahmadi, Hamid Jalilvand, Mohammad Ebrahim Mahdavi, Fatemeh Ahmadi, Ali Reza Akbarzade Baghban Clin Exp Otorhinolaryngol. 2018;11(4):267-274. Original Article June 16, 2018 Full text PubReader ePub PDF Supplementary Material	Triangular Resection of the Upper Lateral Cartilage for Middle Vault Deviation Gwanghui Ryu, Min Young Seo, Kyung Eun Lee, Sang Duk Hong, Seung-Kyu Chung, Hun-Jong Dhong, Hyo Yeol Kim Clin Exp Otorhinolaryngol. 2018;11(4):275-280. Original Article June 2, 2018 Full text PubReader ePub PDF
Efficacy and Safety of Autologous Stromal Vascular Fraction in the Treatment of Empty Nose Syndrome Do-Youn Kim, Hye Ran Hong, Eun Wook Choi, Sang Won Yoon, Yong Ju Jang Clin Exp Otorhinolaryngol. 2018;11(4):281-287. Original Article May 16, 2018 Full text PubReader ePub PDF	Common Sites, Etiology, and Solutions of Persistent Septal Deviation in Revision Septoplasty Hong Ryul Jin, Dae Woo Kim, Hahn Jin Jung Clin Exp Otorhinolaryngol. 2018;11(4):288-292. Original Article July 20, 2018 Full text PubReader ePub PDF
Initial Nutritional Status and Clinical Outcomes in Patients with Deep Neck Infection Marn Joon Park, Ji Won Kim, Yonghan Kim, Yoon Se Lee, Jong-Lyel Roh, Seung-Ho Choi, Sang Yoon Kim, Soon Yuhl Nam Clin Exp Otorhinolaryngol. 2018;11(4):293-300. Original Article July 20, 2018 Full text PubReader ePub PDF Supplementary Material	Body Surface Area Is Not a Reliable Predictor of Tracheal Tube Size in Children Filiz Uzumcugil, Emre Can Celebioglu, Demet Basak Ozkaragoz, Aysun Ankay Yilbas, Basak Akca, Nazgol Lotfinagsh, Bilge Celebioglu Clin Exp Otorhinolaryngol. 2018;11(4):301-308. Original Article August 25, 2018 Full text PubReader ePub PDF

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