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Review

January 25, 2019


Can Endoscopic Tympanoplasty Be a Good Alternative to Microscopic Tympanoplasty? A Systematic Review and Meta-Analysis
Sang-Yeon Lee, Doh Young Lee, Yuju Seo, Young Ho Kim
Clin Exp Otorhinolaryngol. 2019;12(2):145-155.

• Endoscopic ear surgery (EES) have comparable outcomes of graft success compared to microscopic ear surgery (MES).
• EES significantly decreased canalplasty rate, wound complications, and operation time compared to MES did.
• Patients receiving EES reported higher cosmetic satisfaction than patients receiving MES.
• Air-bone gap improved 2.02 dB less in EES than in MES; however, substantial heterogeneity and publication bias limited the integrity of this analysis.
• Our results may affect decision-making and outcome prediction in cases of EES, but confirmation is needed to clarify potential bias.

Original Article

September 1, 2018


Comparison of the Clinical Results of Attic Cholesteatoma Treatment: Endoscopic Versus Microscopic Ear Surgery
Mi Rye Bae, Woo Seok Kang, Jong Woo Chung
Clin Exp Otorhinolaryngol. 2019;12(2):156-162.

• Transcanal endoscopic ear surgery is useful for removing the attic cholesteatoma.
• Hearing improvement and operation time is similar in microscopic and endoscopic surgeries.
• Lempert II endaural incision is not needed in the endoscopic surgery.

Original Article

November 9, 2018


Hyperbilirubinemia and Follow-up Auditory Brainstem Responses in Preterm Infants
Gi-Sung Nam, Sang Hyun Kwak, Seong Hoon Bae, Sung Huhn Kim, Jinsei Jung, Jae Young Choi
Clin Exp Otorhinolaryngol. 2019;12(2):163-168.

• Serial auditory brainstem response (ABR) testing can be a useful, noninvasive methods to evaluate early reversible bilirubin-induced hearing loss in preterm infants.
• Unconjugated bilirubin is a better predictor than total serum bilirubin in preterm infants as evaluated by serial ABR.
• Our results highlight the importance of early detection and careful counselling for bilirubin-induced hearing loss of the preterm infants.

Original Article

October 27, 2018


Effect of Ginkgo Biloba Extract on N-Methyl-D-Aspartic Acid Receptor Subunit 2B Expression in a Salicylate-Induced Ototoxicity Model
Sang-Yeon Lee, Sang Yoon Han, Ye-Ji Shim, Jae-Joon Han, DeukTae Cho, Ji Eun Kim, Young Ho Kim
Clin Exp Otorhinolaryngol. 2019;12(2):169-175.

Sodium salicylate (SS)-induced ototoxicity elicits increased expression of N-methyl-D-aspartate receptor subunit 2B (GluN2B) in the inferior colliculus (IC).
EGb 761, a standard form of Ginkgo biloba extract, decreases the GluN2B protein expression in the IC of SS-induced ototoxicity model based on Western blot.
EGb 761 decreases the expression of immunoreactive GluN2B in the IC of SS-induced ototoxicity model based on immunohistochemistry.
EGb 761 may play a role in regulating the GluN2B expression in the IC of the rat SS-induced ototoxicity model.

Original Article

November 7, 2018


Analysis of Inner Ear Anomalies in Unilateral Congenital Aural Atresia Combined With Microtia
Euyhyun Park, Gijeong Lee, Hak Hyun Jung, Gi Jung Im
Clin Exp Otorhinolaryngol. 2019;12(2):176-180.

• The incidence of inner ear anomalies was relatively high (23.0%) in patients with unilateral congenital aural atresia (CAA) combined with microtia.
• Lateral semicircular canal (LSCC) dysplasia was the most common (16.4%) anomaly in patients with unilateral CAA combined with microtia.
• The Jahrsdoerfer score would show a relationship with the presence of LSCC dysplasia in patients with unilateral CAA combined with microtia. (odds ratio, 0.66; P=0.004).

Original Article

October 20, 2018


Endoplasmic Reticulum Stress Induces MUC5AC and MUC5B Expression in Human Nasal Airway Epithelial Cells
Min Han Kim, Chang Hoon Bae, Yoon Seok Choi, Hyung Gyun Na, Si-Youn Song, Yong-Dae Kim
Clin Exp Otorhinolaryngol. 2019;12(2):181-189.

• Endoplasmic reticulum (ER) stress induces the expression of MUC5AC and MUC5B in human nasal airway epithelial cells.
• The expression of secretary mucins is induced by ER stress via multiple signaling mechanisms.

Original Article

November 13, 2018


Does Rapid Eye Movement Sleep Aggravate Obstructive Sleep Apnea?
Sung Hee Kim, Chan Joo Yang, Jong Tae Baek, Sang Min Hyun, Cheon Sik Kim, Sang-Ahm Lee, Yoo-Sam Chung
Clin Exp Otorhinolaryngol. 2019;12(2):190-195.

• Apnea-hypopnea index (AHI) was the highest during rapid eye movement sleep.
• AHI was significantly higher in the non-rapid eye movement sleep-dominant group.
• Higher AHI was found during deep sleep in 16 of 234 patients (6.8%), differently from previous studies.

Original Article

March 29, 2019


Antiallergic Effect of Hizikia fusiformis in an Ovalbumin-Induced Allergic Rhinitis Mouse Model
Yu-Lian Zhang, Hyun-Jae Shin, Jung-Heon Lee, Jieun Lee
Clin Exp Otorhinolaryngol. 2019;12(2):196-205.

Hizikia fusiformis reduced allergic symptom scores, infiltration of eosinophil, and hyperplasia of goblet cell.
H. fusiformis reduced ovalbumin-specific immunoglobulin E formation.
H. fusiformis reduced interleukin 13 production locally and systemically in allergic rhinitis mouse model.

Original Article

December 27, 2018


Characteristics of Smell Identification Test in Patients With Parkinson Disease
Hisami Fujio, Go Inokuchi, Shun Tatehara, Shunsuke Kuroki, Yuriko Fukuda, Hisamoto Kowa, Ken-ichi Nibu
Clin Exp Otorhinolaryngol. 2019;12(2):206-211.

• Olfaction of patients with Parkinson disease was evaluated by smell identification test (Open Essence).
• Discrepancy between visual analog test and Open Essence was found in patients with Parkinson disease.
• Patients with Parkinson disease tended to select wrong alternatives in Open Essence.

Original Article

November 8, 2018


Clinical Characteristics and Management of Saccular Cysts: A Single Institute Experience
Joo Hyun Kim, Myeong Hee Kim, Hong Geun Ahn, Hong-Shik Choi, Hyung Kwon Byeon
Clin Exp Otorhinolaryngol. 2019;12(2):212-216.

• A saccular cyst is a rare but potentially harmful condition that can lead to airway compromise or malignant transformation.
• Saccular cysts can be mostly managed endoscopically using CO2 laser, without requiring an external approach.

Original Article

December 11, 2018


Development of a Novel Intraoperative Neuromonitoring System Using a Surface Pressure Sensor to Detect Muscle Movement: A Rabbit Model Study
Eui-Suk Sung, Jin-Choon Lee, Sung-Chan Shin, Hyun-Geun Kwon, Min-Sik Kim, Dong-Jo Kim, Jung-Hoon Ro, Byung-Joo Lee
Clin Exp Otorhinolaryngol. 2019;12(2):217-223.

• The risk of nerve damage may occur due to false-negative or false-positive responses on conventional intraoperative neuromonitoring (IONM).
• We developed a novel IONM system using a surface pressure sensor which is to measure the change of surface pressure using a piezo-electric effect instead of electromyography to detect muscle twitching.
• The application of IONM using a surface pressure sensor during surgery is noninvasive, safe, and feasible.

Original Article

December 11, 2018


Role of Immunohistochemistry in Fine Needle Aspiration and Core Needle Biopsy of Thyroid Nodules
Seulki Song, Hyojin Kim, Soon-Hyun Ahn
Clin Exp Otorhinolaryngol. 2019;12(2):224-230.

• Immunohistochemistry (IHC) has been used for the diagnosis of indeterminate results in thyroid nodules.
• Due to the greater tissue availability of core needle biopsy, the IHC staining procedure was more frequently performed with 3–4 simultaneous markers compared to fine needle aspiration.
Current Issue
Volume 12(2); May 2019

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