| Home | E-Submission | Sitemap | Contact Us |  
Clinical and Experimental Otorhinolaryngology > Volume 12(3); 2019 > Article
Park and Won: Voice Outcomes After Transoral Laser Microsurgery or Radiotherapy in Early Glottic Cancer: Factors to Consider
Treatment goals in patients with early glottic cancer include maximizing local control of the disease and preserving the function of the larynx as much as possible. Standard treatments for early glottic cancer include transoral laser microsurgery (TLM) and radiotherapy (RT), which were reported to result in similar oncologic outcomes [1]. More recent studies comparing the two treatment methods, however, have yielded inconsistent findings. For example, one study found that survival was longer in patients with Tis/T1a glottic cancer who underwent TLM than RT [2], whereas another study found that oncologic recurrence rates were higher in patients with T1a and T1b glottic cancer treated with TLM than with RT [3]. In contrast to both, a third study found no difference in 5-year local control rate between TLM and RT in patients with T2 glottic cancer [4]. Nevertheless, the oncologic outcomes of both treatments are excellent in patients with early glottic cancer. Because both TLM and RT provide comparable oncological outcomes, quality of life (QOL) considerations, such as voice outcomes, cost, and duration of treatment, are important in determining the primary treatment modality in individual patients.
Patients with early glottic cancer experience voice changes after both TLM and RT. Many studies have been performed to clarify differences in voice changes between these treatment methods. Although several studies have reported that voice outcomes after TLM are superior to those after RT [5-7], other studies have reported that voice quality is better after RT than after TLM [8-10]. Studies have also found that self-rated voice-related QOL is similar in patients with early glottic carcinoma treated with RT and TLM [11,12], although one of these studies found that objective parameters, including jitter, shimmer, fundamental frequency, and noise/harmonic ratio, are compromised after TLM [11].
One important reason for these conflicting results is the lack of a standard method for evaluating voice outcomes. Some studies used self-assessment tools, such as the Voice Handicap Index (VHI), and perceptual evaluation tools, such as the GRBAS (grade, roughness, breathiness, asthenia, and strain) rating scale. Other studies focused on instrumental assessments, such as laryngeal imaging, acoustic analysis, and aerodynamic assessment. Moreover, studies have reported voice outcomes at different follow-up periods.
Treatment characteristics can also affect voice outcomes. For example, voice outcomes in patients who undergo TLM can depend on the extent of surgical resection. Generally, better VHI outcomes were reported following lower-grade (European Laryngological Society Classification of cordectomies type [ELS] I&II) than higher-grade (ELS III) resection [13], and voice outcomes in patients who undergo RT are affected by radiation dose. Voice outcomes are also affected by individual factors, including smoking status, chronic disease, and previous surgery.
It is not yet possible to determine whether TLM or RT provides superior voice outcomes. Therefore, in making treatment decisions for patients with early glottic cancer, clinicians should consider various factors, including the uncertainties, risks, and benefits of each method, and should fully discuss these factors with their patients.

CONFLICT OF INTEREST

No potential conflict of interest relevant to this article was reported.

REFERENCES

1. Peretti G, Nicolai P, Piazza C, Redaelli de Zinis LO, Valentini S, Antonelli AR. Oncological results of endoscopic resections of Tis and T1 glottic carcinomas by carbon dioxide laser. Ann Otol Rhinol Laryngol. 2001 Sep;110(9):820–6.
crossref pmid
2. Guimaraes AV, Dedivitis RA, Matos LL, Aires FT, Cernea CR. Comparison between transoral laser surgery and radiotherapy in the treatment of early glottic cancer: a systematic review and meta-analysis. Sci Rep. 2018 Aug;8(1):11900.
crossref pmid pmc pdf
3. Gioacchini FM, Tulli M, Kaleci S, Bondi S, Bussi M, Re M. Therapeutic modalities and oncologic outcomes in the treatment of T1b glottic squamous cell carcinoma: a systematic review. Eur Arch Otorhinolaryngol. 2017 Dec;274(12):4091–102.
crossref pmid pdf
4. Warner L, Lee K, Homer JJ. Transoral laser microsurgery versus radiotherapy for T2 glottic squamous cell carcinoma: a systematic review of local control outcomes. Clin Otolaryngol. 2017 Jun;42(3):629–36.
crossref pmid
5. Du G, Liu C, Yu W, Li J, Li W, Wang C, et al. Voice outcomes after laser surgery vs. radiotherapy of early glottic carcinoma: a meta-analysis. Int J Clin Exp Med. 2015 Oct;8(10):17206–13.
pmid pmc
6. Gandhi S, Gupta S, Rajopadhye G. A comparison of phonatory outcome between trans-oral CO(2) laser cordectomy and radiotherapy in T1 glottic cancer. Eur Arch Otorhinolaryngol. 2018 Nov;275(11):2783–6.
crossref pmid pdf
7. Hong YT, Park MJ, Hong KH. Characteristics of speech production in patients with T1 glottic cancer who underwent laser cordectomy or radiotherapy. Logoped Phoniatr Vocol. 2018 Oct;43(3):120–8.
crossref pmid
8. Jotic A, Stankovic P, Jesic S, Milovanovic J, Stojanovic M, Djukic V. Voice quality after treatment of early glottic carcinoma. J Voice. 2012 May;26(3):381–9.
crossref pmid
9. Kerr P, Mark Taylor S, Rigby M, Myers C, Osborn H, Lambert P, et al. Oncologic and voice outcomes after treatment of early glottic cancer: transoral laser microsurgery versus radiotherapy. J Otolaryngol Head Neck Surg. 2012 Dec;41(6):381–8.
pmid
10. Lee SH, Hong KH, Kim JS, Hong YT. Perceptual and acoustic outcomes of early-stage glottic cancer after laser surgery or radiotherapy: a meta-analysis. Clin Exp Otorhinolaryngol. 2019 Aug;12(3):241–8.
crossref pdf
11. Lombardo N, Aragona T, Alsayyad S, Pelaia G, Terracciano R, Savino R. Objective and self-evaluation voice analysis after transoral laser cordectomy and radiotherapy in T1a-T1b glottic cancer. Lasers Med Sci. 2018 Jan;33(1):141–7.
crossref pmid pdf
12. Osborn HA, Hu A, Venkatesan V, Nichols A, Franklin JH, Yoo JH, et al. Comparison of endoscopic laser resection versus radiation therapy for the treatment of early glottic carcinoma. J Otolaryngol Head Neck Surg. 2011 Jun;40(3):200–4.
pmid
13. Kinshuck AJ, Shenoy A, Jones TM. Voice outcomes for early laryngeal cancer. Curr Opin Otolaryngol Head Neck Surg. 2017 Jun;25(3):211–6.
pmid
TOOLS
PDF Links  PDF Links
PubReader  PubReader
ePub Link  ePub Link
Full text via DOI  Full text via DOI
Download Citation  Download Citation
CrossRef TDM  CrossRef TDM
  E-Mail
  Print
Share:      
METRICS
0
Crossref
0
Scopus
154
View
14
Download
Related article
Editorial Office
Korean Society of Otorhinolaryngology-Head and Neck Surgery
103-307 Park Tower officetel, Yongsan-dong 5-ga, Yongsan-gu, Seoul 04385, Korea
TEL: +82-2-711-9091   FAX: +82-2-3487-6603   E-mail: editor.eceo@gmail.com
Copyright © Korean Society of Otorhinolaryngology-Head and Neck Surgery. All rights reserved.                 Developed in M2Community
Close layer
prev next