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Clinical and Experimental Otorhinolaryngology > Volume 14(1); 2021 > Article
Shukor, Lee, Seo, and Han: Efficacy of Music Training in Hearing Aid and Cochlear Implant Users: A Systematic Review and Meta-Analysis


This study aimed to evaluate the efficacy of music training on the improvement of musical perception among hearing-impaired listeners using a systematic review and meta-analysis. Article search was conducted from five databases, Scopus, ScienceDirect, Web of Knowledge, CINAHL, and PubMed. A total of 186 participants from 10 studies investigating the music training effects on individuals fitted with hearing assistive devices and outcome measurements were included. The meta-analysis showed standardized mean difference as a measure of the effect size, in musical improvement between the preand post-training. Although the funnel plot yielded an asymmetrical graph, the Egger’s regression showed no significant publication bias. Interestingly, subgroup analysis showed that the training effect was greater in children than in adults. With a necessity of longer training period to significantly improve their musical perception, cochlear implant only users had better effect compared to bi-modal users with both cochlear implant and hearing aids. However, the difference in the training effect between the users with and without previous musical experience was nonsignificant. The present study concludes that auditory music training brings hearing-impaired listeners into better musical perception while informing that training effects differ depending on age, duration of the training, and the type of hearing device used.


Disabling hearing loss is a common problem faced by over 466 million people throughout the world, accounting for 6.1% of the world’s population [1]. The effect of hearing loss on an individual is highly dependent on the severity of the loss, the individual’s lifestyle and communication needs, and other factors [2]. Most people suffering from hearing loss can benefit from advanced hearing assistive devices, such as hearing aids and cochlear implants, which record sounds from the surrounding environment, adapt the signal to compensate for the characteristics of the user’s hearing loss, and replay the adapted sounds into the user’s ear [3]. The primary therapeutic needs of individuals with hearing devices include a better understanding of speech [4].
Aural (re)habilitation is one of the key factors in improving communication skills and promoting the normal development of the speech-language of hearing device users [5]. In the last two decades, studies have investigated music as an auditory training approach. Interestingly, the part of the brain that plays a major role in perceiving speech also plays an important role in the processing of music and other meaningful auditory signals [6,7]. Confirming that speech and music share neural networks, Gfeller [6] suggested that listening to or performing music might have a positive effect on the development of more efficient and robust auditory processes. In addition, Anderson and Kraus [7] found that the perceptual requirements associated with music listening also had implications for auditory training. In light of these results, significant interest has emerged in adapting music training for aural (re)habilitation [8]. Although the significant effects of music training have led to further clinical research on whether it can improve speech and/or musical perception as an aural (re) habilitation approach [9], many early studies only explored the role of sub-cortical responses in the detection of musical elements, such as pitch, frequency, timing, and timbre [10]. Further, no previous studies reported specific and concrete findings regarding the clinical implications of music training and its effects in hearing-impaired listeners who wear hearing devices.
Herein, we aimed to determine the therapeutic efficacy of music training in patients with hearing loss who have been fitted with hearing aids, cochlear implants, or both devices, through a systematic review and meta-analysis. Furthermore, another purpose of the present study was to assess potential positive clinical effects of music training based on users’ age, the type of hearing device, musical experience before training, and training period.


Search strategy

The systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement [11]. Articles search of the five databases, e.g., Scopus, ScienceDirect, Web of Knowledge, CINAHL, and PubMed, was done systematically in October 2019. The articles that been included in this study have been published from year 1980 to 2019. Table 1 provides full electronic search strategies with a string of keywords.

Eligibility criteria and study selection

The inclusion criteria for studies in the review were specified in terms of participants, interventions, comparisons, outcomes, and study design (PICOS) as follows [11]. Studies were included in the systematic review if they (1) involved individuals (children and adults) with hearing loss fitted with hearing aids or cochlear implant unilaterally or bilaterally, (2) included participants who underwent music training as rehabilitation, (3) compared preand post-rehabilitation effect or repeated measures (experiments with additional purposes), (4) incorporated outcome measure(s) related to speech perception/intelligibility, auditory perception, musical perception, or communication improvement, and (5) integrated study design of randomized controlled trials, non-randomized controlled trials, cohort studies, and repeated measures (experiments with additional purposes) to report the results of pre- and post-training.
Titles and abstracts of the articles were screened according to the selection criteria and identified for preliminary articles as inclusion. Additional information was identified manually by two independent authors (NFAS and WH) who also checked any relevant articles that may not have been returned by the initial database search.

Data extraction

Two authors independently extracted data from each study following PICOS criteria [11]. Both children and adult participants who had hearing loss and have been fitted with either hearing aids or cochlear implants were included as the participants. In the intervention, all studies included the music training sorted by the stimuli used, frequency, duration of the training, and study settings of music training. All outcome measures related to musical perception after conducting the music training were collected. For comparison, we used pre- and post-training results to study the effectiveness of the music training. No restrictions were specified in terms of the duration of rehabilitation and follow-up. Finally, primary outcomes included one or more of the following: (1) detection of music perception including pitch, rhythm, frequency discrimination, and melody; (2) improvement in music perception including pitch, rhythm, frequency discrimination, and melody; (3) improvement in melodic contour identification that indicates tone recognition and speech perception; (4) improvement in the perception of recognition of musical instruments. Secondary outcomes comprised the improvement in musical performance, i.e., singing and music appreciation.

Risk of bias and quality of study

The methodological quality and risk of bias for the included studies were assessed using the standardized Physiotherapy Evidence Database (PEDro) scale. This scale’s items assessed the (1) specific eligibility criteria, (2) randomization of the allocation of the subjects, (3) concealed allocation of subjects, (4) pretherapeutic interventions baseline, (5) blinding of all subjects, (6) blinding of therapists, (7) blinding of assessors who measured key outcomes of the study, (8) measure of at least one key outcome form 85% of the recruited subjects, (9) intention to treat analysis (mentions that all subjects received treatment or control conditions as allocated, (10) statistical comparison between groups for at least one key outcome, and (11) point measure for size of treatment effect and variability measure for at least one key outcome.
One point was added to the studies only if a criterion was clearly stated on literal reading. The point would not be added if the criteria were missing or not clearly stated. For criteria 4 and 7 through 11, key outcomes provided the primary measure of the effectiveness or lack of the effectiveness of the therapy. Based on the suggestion of Moseley et al. [12], studies scoring 9–10 on the PEDro scale were considered methodologically to be of “excellent” quality. Scores ranging from 6 to 8 were considered “good” quality, while studies scoring 4 or 5 were of “fair” quality, and studies scoring below 4 were considered “poor” quality.

Statistical analysis and publication bias

Data analysis was run using Comprehensive Meta-Analysis ver. 3 (Biostat Inc., Englewood, NJ, USA). Meta-analysis was performed using all studies that contained musical perception data having pre- and post-music training, appropriate outcome measures, and intervention. Means and standard deviation of preand post-training and also their correlation were used to calculate effect size of the music training.
Since most studies employed different measures outcome for musical perception, the effect sizes were calculated as standardized mean difference (SMD) in which it is necessary to standardize the result of all the studies to uniform scale before they can be combined; thus SMD expresses the size of the intervention effect in each study relative to the variability observed in that study [13]. All effect sizes were pooled using a random-effects model with 95% confidence intervals (CIs) [14]. A mixed-effects Q test for between-subgroup analysis of variance was used to compare the effects of four subgroups [14]. The funnel plot and Egger’s regression asymmetry test were used to assess publication bias [15].

Heterogeneity analysis

Cochrane’s Q and I2 values were calculated to test for homogeneity of variance across the studies. The Q value represented the total amount of variance among the set of studies. I2 was calculated using the formula, I2 =100%·(Q–df)/Q. According to Higgins and Altman [13], it provided a precise and easily interpreted measure of heterogeneity. I2 values of 25%, 50%, and 75% represented low, medium, and high heterogeneity, respectively. A significant Q value indicated that the data were heterogeneous.


The search returned 9,021 articles, the titles of which were screened for relevance to the topic. After eliminating duplicate articles, a total of 4,092 articles remained. Subsequently, the following criteria were used to screen for eligibility. After first screening the titles and abstracts, 4,044 articles were excluded from the fulltext assessment. A preliminary review of those titles narrowed down the potentially relevant articles to 48 journal articles, the full text of which could be accessed. The full texts of the remaining articles were then reviewed for inclusion based on the PICOS criteria and relevance. After applying our inclusion and exclusion criteria, 15 articles were left. Fig. 1 presents the selection process of the articles. Five studies were then excluded due to unsuitable outcome measures; thus, 10 full articles were included in this meta-analysis.

Characteristics of studies in the meta-analysis

Ten studies involving 186 participants met the PICOS inclusion criteria. The participants consisted of both adult and pediatric patients with hearing loss who had been fitted with hearing aids and cochlear implants. The age of the 101 adult participants who had consistently used hearing aids before post-lingual cochlear implantation [16-19] ranged from 18 to 88 years old, and the age of the 85 children ranged from 1 to 15 years old [20-25]. Among the participants, 89 were female and 76 were male; however, the sex of 21 participants in two studies by Fuller et al. [16] and Yucel et al. [23] was not specified.
The music training programs used in these studies consisted of various kinds of stimuli and musical programs. Fu et al. [22] and Yucel et al. [23] used musical tones as stimuli, while the training stimuli in two other studies consisted of musical instrument tones at low, mid, and high frequencies [17,24]. Three studies directly measured cochlear implant users’ melodic perception using a melodic contour identification task [16,18,25], and three other studies conducted self-developed music training to enhance perceptual detection and to evaluate its improvement [19-21].
Most studies had a training period of 5 weeks to 3 months [16-18,22,25], while two studies [20,21] utilized training that lasted 3 months to 11 months, which were classified as an intermediate duration, and other two studies conducted training with a long duration (more than 12 months) [23,24]. Five studies were conducted in home settings [17,18,21-23] and the other studies implemented the training in rehabilitation centers [10,16,19,24,25]. The characteristics of the 10 studies are summarized in Table 2.

Overall effectiveness of music training

The outcomes of each study are also summarized in Table 2. In the pooled analysis (Fig. 2A), participants’ musical perception was significantly higher after music training (SMD=2.092, 95% CI, 1.333–2.850, P<0.001). Although a funnel plot showed that the data were asymmetrical (Fig. 2B), the Egger regression test detected no publication bias in the studies (intercept=2.313; standard error, 1.376; P=0.1312). Due to high heterogeneity (I2=86.57), we conducted a subgroup analysis.

Subgroup analysis

Four subgroup analyses were conducted to investigate the effects of age, the hearing device used, the participants’ musical experience before the training, and music training duration on improvements in musical perception. Table 3 presents the effect sizes for subgroups, 95% CIs, and heterogeneity.


To investigate the effects of age, the participants were divided into adults (age ≥18 years) and children (age <18 years). Fig. 3A presents a subgroup analysis of the effect of age on the outcome of musical perception after music training. A statistically significant subgroup effect was found (P=0.013), indicating that the effect of music training was different according to participants’ age. The rehabilitation effect was greater for children than for adults. The pooled effect size estimated for adults (SMD=1.118; 95% CI, 0.014–2.21) was notably lower than that of children (SMD=2.658; 95% CI, 1.640–3.676), implying that the treatment effect was stronger in children than in adults.

Hearing devices

Hearing device users were divided into those with a cochlear implant only and those with a cochlear implant and hearing aid (i.e., bi-modal users). The pooled data for the hearing device subgroups are shown in Fig. 3B. Unfortunately, due to moderate to substantial heterogeneity between the trials within each of these subgroups and the relatively small number of participants, the results obtained might have failed to detect subgroup differences precisely. Regardless, the effect size for cochlear implant– only users was notably larger (SMD=2.232; 95% CI, 1.170–3.295) than that for bi-modal users (SMD=1.640; 95% CI, 0.395–2.885), which indicates that a stronger treatment effect of music training was observed for cochlear implant–only users than for bi-modal users.

Previous musical experience

A subgroup analysis according to previous musical experience showed no statistically significant difference (P=0.052), indicating that participants’ musical experience before music training did not affect the effectiveness of training (Fig. 3C). Nonetheless, the plausibility of this subgroup effect should be considered, as substantial heterogeneity was found among the trials within each of these subgroups (without musical experience: I2=77.77%; with musical experience: I2=80.66%).

Training period

The studies were divided according to three training periods (short, intermediate, and long). The training period showed a significant effect (P=0.004), with low heterogeneity (I2=24.51%), indicating that training duration might significantly affect training effectiveness in terms of musical perception (Fig. 3D). A long duration of training showed notably stronger effects (SMD=3.583, 95% CI, 1.973–5.193) than a short duration of training (SMD=1.791, 95% CI, 0.949–2.633), which implies that long-duration music training is more effective as a treatment than short-duration training. Intermediate-duration training, lasting from 3 months to 11 months, had the smallest effect size (SMD=0.941, 95% CI, –0.392 to 2.275).

Risk of bias and quality of evidence assessment

Table 4 shows the quality scores for each question of the PEDro. Two authors independently analyzed the scores and then verified them on the official PEDro website. The overall mean PEDro score was 6.5. The quality of the articles ranged from fair to good, with the quality of two studies being assessed as fair [18,24] and the quality of the remaining studies classified as good [16,17,19-23,25] due to a lack of information about the random allocation of subjects, the blinding process, and whether the key outcome were analyzed by “intention-to-treat” or not. None of the studies provided information about the blinding of the therapists involved in therapy sessions (i.e., whether they were unable to distinguish between the treatments applied to different groups) or about the subject concealment.


Is music training effective as aural rehabilitation for hearing aid and cochlear implant users?

Music therapy can address several objectives of auditory training. Previous studies have suggested that music training can improve perception, localization, differentiation, and recognition of sound and attention towards the sound [5]. Furthermore, appropriate musical input is more effectively heard and assimilated than speech; thus, it is more likely to stimulate a natural motivation to use residual hearing [6]. The present study evaluated the efficacy of music training on musical perception among individuals with hearing loss who had been fitted with either hearing aids, cochlear implants, or both. The synthesis of data from these 10 studies suggested that significant improvements in musical perception were achieved in these individuals. Significant differences emerged according to age (between adults and children), the type of hearing device used, and the duration of training. However, nonsignificant differences in terms of improvements in musical perception were observed between participants with musical experience and those with no musical experience before starting music training.

Does music therapy affect adult and pediatric patients differently?

A significantly different effect of music training was found between children (below 18 years of age) and adults (18 years of age and older). The effect size for children was significantly larger than that for adults, suggesting that music training may provide greater benefits for children than for adults. From the perspective of neuroplasticity, it is logical that pediatric users of hearing aids and cochlear implants may benefit more from music training than adult users [6]. Chronological age has long been linked to neuroplasticity, with greater neuroplasticity associated with younger age and/or immaturity [26]. The capacity for synaptic plasticity, with consequences for learning and memory, is not constant throughout the lifespan and typically declines with age at variable rates [27]. It peaks relatively soon after birth, with some research indicating that infants’ brain plasticity is about two times higher than that of adults. The effects of music training in children might therefore be stronger due to their greater brain plasticity. A clear differentiation of the effects of musical therapy across different age groups would help in the development and implementation of programs according to patients’ needs. In addition to age, however, it would have been desirable to consider in this study whether individuals were affected by pre-lingual or post-lingual deafness. In previous studies, significantly different therapeutic effects have been found for these two groups [26]. However, due to limitations in the data that could be extracted, it was not possible to clearly subcategorize the participants into pre-lingual and post-lingual deafness groups. Future research comparing differences between individuals with pre-lingual and post-lingual deafness through high-quality randomized controlled trials is needed to confirm the therapeutic effectiveness of aural rehabilitation in these two groups.

Can the type of hearing assistive device influence the effects of music training?

The usage of different hearing assistive devices is known to be linked to differences in speech recognition performance by hearing-impaired individuals. Research by Gfeller et al. [28] found that bilateral cochlear implants provided a positive impact on the recognition of music with lyrics, whereas bi-modal users who were fitted with hearing aids and cochlear implants showed better perception and enjoyment of instrumental music. This finding provides natural support for the possibility that the perception of music is likely to be meaningfully improved by combining acoustic and electric stimulation.
Regardless, the current study found that the trainees who used only cochlear implants showed greater improvements in musical perception after music training than those who used both cochlear implants and hearing aids. One possible explanation for this seemingly contradictory finding is that most trainees who were only fitted with cochlear implants in this study were young children. As discussed above, the effects of music training differed between children and adults due to neuroplasticity. Therefore, in further research, music training should be applied to carefully differentiated subgroups among participants of the same age depending on the mode and type of devices.

Is previous musical experience a key factor for inducing positive results of music training?

A nonsignificant effect of previous musical experience on trainees’ musical perception was found. However, the authors suggest that it may not be possible to draw a definitive conclusion for this subgroup because of the high level of heterogeneity that was present among the relevant studies. For example, the studies did not provide clear and specific information on how long and how often the trainee had musical experience and how intensive their experience was. Furthermore, the effects of music on the brain have been previously investigated by several researchers who compared the brain structure of musicians and non-musicians. For instance, in the study conducted by George and Coch [29], musicians demonstrated faster updating of auditory and visual working memory representations and more efficiently drew upon working memory resources to process deviant auditory stimuli than non-musicians with no musical experience.
The relationship between previous musical experience and the results of music training still need to be further explored through high-quality evidence-based studies, such as randomized controlled trials with a larger number of participants, as it remains possible that musical experience may have a significant effect on the outcomes of music training.

Is there a most effective duration of music training?

We analyzed the effectiveness of music training in terms of the training period. From the pooled results in this subgroup analysis, short and long training durations had a significant positive effect on improving participants’ musical perception, whereas a nonsignificant effect was observed for the intermediate duration. From the perspective of audiological practice, we suggest a long training duration (e.g., 12 months or longer) to optimize the effectiveness of rehabilitation programs for hearing-impaired individuals. The effects of various training durations on the effectiveness of music training are expected to serve as a basis for the development of further music training programs to improve the auditory perception of hearing-impaired individuals with hearing devices.

Limitations of the study

The studies included in this review varied in terms of the severity of the disease, the type and duration of intervention, and the quality of the methodology; therefore, caution is needed when interpreting our findings. The outcome measure of musical perception was used to assess the efficacy of music training among individuals with hearing loss. Participants’ listening abilities, duration of the training, and the content of training varied considerably across studies. This not only resulted in a limited ability to make direct comparisons but may also explain the inconsistent pattern of results that was observed across studies. Furthermore, because of the limited number of suitable articles that have been published, the number of participants was rather small and may not represent the entire population. Moreover, we only included studies that were published in English. In light of the small number of trials and participants and heterogeneity among studies, we still do not have enough evidence to confidently conclude whether there is a true subgroup effect for the type of device and musical experience. It is, therefore, useful to consider the plausibility of the demonstrated subgroup effects for these two groups. High heterogeneity is expected due to differences across studies, but it can nonetheless be useful to present the pooled data from comparable studies.

Future directions of auditory training with music

The findings of this systematic review regarding the effectiveness of music training in terms of improvements in musical perception can provide further directions for research in this field. We believe that the effectiveness of music training for the improvement of musical perception may be linked to the effectiveness of music training in aural rehabilitation and speech-language development because speech and music share many common properties. The auditory perception of speech and music involves the ability to distinguish between different sounds, their pitches, duration, intensities, and timbres, and their changes over time [6]. These properties enhance the listener’s ability to interpret sounds and attach meaning to them. Furthermore, these commonalities between music and speech allow music and music therapy to provide an alternative and pleasurable tool to enhance traditional auditory training techniques. Specifically, based on the studies reviewed herein, patients’ discrimination levels significantly improved through music training, and the practice that patients received in the setting of music generalized to environmental sounds.
Overall, music training can be implemented as an aural rehabilitation approach, as it effectively improves aural perception and musical perception in patients with hearing loss. In addition, it is important to consider that the effects of music training differ by the age of the trainee, the type of hearing device used, and the duration of music training. The finding of this study can serve as a reference for clinicians, patients, and health policymakers regarding the application of music training in clinical or rehabilitation programs. However, further high-quality randomized controlled trials are needed to confirm the effectiveness of aural rehabilitation in hearing-impaired patients.


▪ In patients with hearing loss, music training should be considered as auditory training as it can improve their musical perception.
▪ Compared to adults with hearing loss, the pediatric patients showed greater benefits from the music training.
▪ Cochlear implant users have a greater effect on music training compared to the bimodal users.
▪ Unexpectedly, the previous musical experience was not a significant factor in their music training.
▪ Long duration of the music training (at least longer than 12 months) provides better performance in terms of musical perception.


This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (2019R1F1A1053060).


No potential conflict of interest relevant to this article was reported.



Conceptualization: all authors. Data curation and formal analysis: NFAS, WH. Funding acquisition: WH. Methodology: NFAS, JL. Project administration: YJS, WH. Visualization: NFAS, JL. Writing–original draft: NFAS. Writing–review & editing: all authors.

Fig. 1.
Flow diagram of studies selected for the systematic review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. PICOS, participants, interventions, comparisons, outcomes, and study design.
Fig. 2.
Forest plot of a pooled analysis of all 10 included studies (A), and a funnel plot of standard errors by the standardized difference (std diff) in means yielded an asymmetrical graph, indicating potential publication bias (B). MCI, melodic contour identification; CI, confidence interval.
Fig. 3.
Subgroup analysis. Effect sizes according to age group (A), hearing device (B), previous musical experience (C). CI, confidence interval; std diff, standardized difference; MCI, melodic contour identification. Subgroup analysis. Effect sizes according to the duration of music training (D). CI, confidence interval; std diff, standardized difference; MCI, melodic contour identification.
Table 1.
Full electronic search strategies for all databases used in the study
Database Keyword
PubMed, Scopus, Web of Knowledge, CINAHL “Music” OR “Music Training” OR “Music therapy” OR “Acoustic Stimulation” OR “Auditory Training” OR “Auditory Rehabilitation” OR “Auditory stimulation” OR “Musical Stimulation” AND “Speech perception” OR ”Speech improvement” OR “Auditory perception” OR “Music perception” OR “Speech intelligibility” OR “Loudness perception” OR “Pitch perception” OR “Pitch discrimination” AND “Training time” OR “Training duration” OR “Training content” OR “Musical exposure” OR “Music Content”
ScienceDirect “Music Training” OR “Music therapy” OR Auditory Training” AND “Auditory perception” OR “Music perception” OR “Speech intelligibility” OR “Loudness perception” AND Training duration” OR “Training content”
“Acoustic Stimulation” OR “Music therapy” OR “Musical Stimulation” AND “Speech improvement” OR “Music perception” OR “Loudness perception” OR “Pitch perception” AND “Training content” OR “Musical exposure” OR “Music Content”
Table 2.
Comparison of participants’ characteristics and training outcomes in the 10 included studies
Study Design Participant
Intervention: music training
Study setting Outcome Finding
Hearing loss and hearing device No. of participants, age and sex Control group Stimuli Frequency and duration
Yucel et al. (2009) [23] Randomized controlled trial Profoundly hearing-impaired children n=18 (music group: 9) Normal hearing children: n=9 An electronic keyboard (YAMAHA PSR-295) 10 min/day every day for 2 years Home training Improvement of musical perception (pitch, rhythm, and melody) Music group:
Age: not specified Ling’s six-sound detection (P<0.05)
Unilaterally implanted with cochlear implants; HiRes stimulation mode Age at implantation: 39–96 months Listening to two pairs of notes Evaluation after 1, 3, 6, 12, and 24 months (24 months) Word identification (P<0.05)
Age: not specified Based on note discrimination Daily sentences (P>0.05) (not significant)
Sex: NA Music stage questionnaire (P<0.05)
Di Nardo et al. (2015) [21] Experimental study (repeated measure) Bilateral hearing loss n=10 (6 boys, 4 girls) None Auditory music training program (home-learning program) 6-Month training period Home training Improvement in musical perception (frequency discrimination, pitch recognition, and appraisal) Musical pitch discrimination test showed a significant improvement in musical perception after music training (P=0.001)
Mono-aural nucleus CI users Age: 5–12 years Frequency bands: 262–523 Hz, 523–1,046 Hz, and 1,046–1,976 Hz (used for most of the song, 36 notes) At least 2 hours weekly (6 months)
Hearing age with CI, ±26 months Music test result (pre-and post-training: P=0.015) (melodic version: P=0.007)
Fu et al. (2015) [22] Repeated measures Children with congenital hearing loss n=14 (boys: 7 girls: 7) None Five tones, three tones, five piano stimuli (different root notes used for training) Half-hour per day Home training MCI Mean performance improved for all outcome measures
Mandarin-speaking Age: 5.5–9.7 years (mean, 7.8 years) 23 Root notes (250 ms with 50 ms of silence between each note) Every day for 10 weeks 2.5 months Tone recognition and speech perception Five tones (mean improvement, 57.3 points; SE, 11.1)
Had at least 2 years of experience with CI Mean CI usage: 4.9 years (2.3–7.7 years) All stimuli presented at 70 dBA Three tones (mean improvement, 45.8 points; SE, 10.9)
Five piano stimuli (mean improvement, 45.8 points; SE, 8.2)
Cheng et al. (2018) [25] Non-randomized controlled trial Mandarin-speaking CI children CI group: n=16 (5 girls, 11 boys) Normal group n=22 (11 girls, 11 boys) (1) MCI stimuli: nine melodic contours (rising, rising-flat, rising-falling, flat-rising, flat, flat-falling, falling-rising, falling-flat, falling) Five notes of equal duration (250 ms, 50 ms of silence between notes) 15 min/session Rehabilitation center Music (MCI and tone recognition) and speech perception (sentence recognition) Significant effect recorded for
Prelingually deaf and diagnosed with severe-profound SNHL before 1 year old Age: 1.7–6.1 years; mean, 6.3 years Age: 4.5–9.3 years; mean, 6.2 years Three sessions per training day (1) MCI mean improvement: 22.0 (range, 5.7–47.2)
CI experience: 0.8–6.0 years; mean, 2.8 years (2) Lexical tone stimuli: 64 stimuli (4 tones×4 monosyllables×4 talkers) 5 day/wk for 8 weeks 2 months (2) Tone recognition: 14.5 (range, 4.7–32.8)
(3) Sentence recognition: 14.5 (range, 1.5–34.3)
Fuller et al. (2018) [16] Randomized controlled trial Dutch-speaking adults who were CI users (1) Pitch/timbre group (n=6); age: 56–73 years; CI experience: 5–11 years Control (non-music training), n=4 (1) Pitch and timbre: 2 hr/session (15-minute break) Rehabilitation center (1) Word identification (1) Word identification:
Used CI more than 1 year Age: 66–80 years MCI (five training sessions) Weekly session for 6 weeks 1.5 months Timbre: P<0.001
Some participants used hearing aids in the contralateral ear. (2) Music group (n=6); age: 59–71 years; CI experience: 3–10 years CI experience: 4–6 years MCI: one test (2) Sentence identification (both consisting of speech perception) Music: P=0.708
Instrument identification/daily sound identification Overall: P=0.005 (significant)
MCI (five training sessions) (2) Sentence identification:
MCI (one test) Timbre: P=0.339
(2) Music therapy Music: P=0.328
Listening to music and emotional speech Overall: P<0.05 (significant)
Listening to musical speech
Playing an instrument
Improvising music
Session questionnaire
Driscoll (2012) [17] Randomized controlled trial Post-lingual deaf adults aged >18 n=71 (21 men, 50 women) n=24, feedback on correct musical cues Recording of solo performance of eight musical instruments: 15 Sessions Home training Improved recognition of musical instruments (1) Musical background questionnaire recognition test: Week 3: significant difference observed (P<0.001)
Read/understand written English Age: 26–88 years (mean, 62.59 years) (1) Representing a range of low, middle, and high frequencies 10 min/session (2) Significant improvement observed from week 3 to week 5 (P=0.011)
Have access to a computer with internet and sound capabilities Bilateral: 21, unilateral: 50 (2) Five melodies from each instrument Three times/wk over 5 weeks 1.2 months No significant improvement in timbre recognition (3) Individuals with bilateral CI scored significantly higher than those with unilateral CI (P=0.02)
Used CI, HA, or both Divided into three groups
Galvin et al. (2007) [18] Non-randomized controlled trial Adults with no musical experience n=6 (4 men, 2 women) n=9 Melodic contour identification training (nine five-note melodic patterns) 4 subjects: 30 min/day; everyday (1 to 2 months) Home training Rehabilitation center Improvement in: MCI performance (percent correct): 15.5%–45.4% improvement FMI performance: with rhythm cues: 9.1% improvement (P=0.373, not significant) Without rhythm cues: 20.8% improvement (P=0.020, significant)
CI users Wearing CI Normal hearing Two subjects: 3 hours per day, 1 week 2 months MCI performance (vowel recognition)
Age: 26–75 years FMI test (music perception performance)
Hutter et al. (2015) [19] Experimental study (repeated measures) Adults >18 years n=12 (6 women, 6 men) No control group Five modules of music therapy: 10 Individualized sessions Rehabilitation center Hearing performance in musical parameters (1) Pitch discrimination: P=0.027 (no significant difference)
Post-lingual deafness, Age: mean, 54 years (1) Variability of voice and speech 50 min/session (1) Pitch discrimination (2) Melody recognition: P<0.018 (significant)
Unilaterally implanted CI users (2) Diverse components of music (2) Melody recognition (3) Timbre identification: P=0.004 (significant but only in unilateral CI users)
(3) Playfully used components of speech (3) Timbre identification
(4) Speech in diverse hearing surroundings
(5) Complex hearing
Kosaner et al. (2012) [24] Experimental study (repeated measures) Pediatric CI n=25 No control group Live or recorded music Each group: a set of six songs and six rhymes Groups A and B participated with parents in one group session (45 minutes, one individual session of 20–30 min/wk for 18 months). Rehabilitation center Improvement in performance of the musical component Recognizing song, tunes, and timbre
Unilaterally implanted CI users Divided into three groups: Tonal music with range pitch, timbre, intensity, and frequency Responding to music and rhythm
Group A: n=12 (3 girls, 9 boys; mean age: 26 months) Music associated with animals and actions and stories related to music was created. Group C: one group and one individual session/wk for 3 months Singing
Group B: n=7 (5 girls, 2 boys; mean age: 43 months) Overall improvement
Group C: n=6 (3 girls, 3 boys; mean age: 72 months) Group A: P<0.001
Group B: P<0.001
Group C: P=0.027
Innes-Brown et al. (2013) [20] Non-randomized controlled study School-age children n=11 (4 girls, 7 boys) (CI: 6, HA: 5) n=9 Normal hearing (5 girls, 4 boys) The “music club”: musical activities based on round play Conducted every week, 45 min/session Rehabilitation center Auditory perception (rhythmic, tonal, and timbre perception) Rhythmic test: pre-post training: P<0.01
Using HA and CI Session were divided into vocal play, physical music, and singing games. Tonal test: pre-post training: P=0.04
All games targeted rhythm, tempo, pitch, and timbre. Timbre test: pre-post training: P=0.01

NA, not applicable; CI, cochlear implant; MCI, melodic contour identification; SE, standard error; SNHL, sensorineural hearing loss; HA, hearing aid; FMI, familiar melody identification.

Table 3.
Summary of the meta-analysis by effect size and heterogeneity, including four subgroup analyses
Characteristics Study (n) Effect size and 95% CI
Homogeneity test
SMD Lower limit Upper limit P-value Q Df (Q) P-value I2
Overall 10 2.092 1.333 2.850 <0.001 67.014 9 <0.001 86.570
Age 1.903 0.3412 3.412 0.013 25.523 5 0.090 39.420
 Adult 4 1.118 0.014 2.221 0.047 12.769 3 0.005 16.506
 Children 6 2.658 1.640 3.676 <0.001 38.370 5 <0.001 18.969
Device 1.862 0.550 3.174 0.005 45.610 7 <0.001 63.791
 Cochlear implant only 6 2.452 1.450 3.453 <0.001 43.600 5 <0.001 58.532
 Cochlear implant and hearing aid 4 1.101 –0.274 2.476 0.116 11.680 3 0.009 44.315
Musical experience 1.872 –0.017 3.762 0.052 51.523 9 0.003 83.791
 Yes 4 0.909 0.011 1.806 0.047 15.510 3 0.001 77.774
 No 6 2.837 1.935 3.738 <0.001 22.497 5 <0.001 80.658
Music training period 2.023 0.661 2.911 0.004 31.334 9 0.131 24.510
 <3 mon 6 1.791 0.949 2.633 <0.001 33.074 5 <0.001 22.882
 >3 to <12 mon 2 0.941 –0.392 2.275 0.167 1.906 1 0.467 21.536
 ≥12 mon 2 3.583 1.973 5.193 <0.001 0.000 1 0.996 0.000

CI, confidence interval; SMD, standardized mean difference.

Table 4.
Quality assessment based on the PEDro scale for the 10 included studies
Study 1 2 3 4 5 6 7 8 9 10 11 Total Quality
Hutter et al. (2015) [19] 1 1 1 1 0 0 0 0 1 1 1 7/11 Good
Innes-Brown et al. (2013) [20] 0 0 1 0 1 0 0 1 1 1 1 6/11 Good
Kosaner et al. (2012) [24] 0 0 0 1 0 0 0 1 1 1 1 5/11 Fair
Galvin et al. (2007) [18] 0 1 1 0 0 0 0 1 0 1 1 5/11 Fair
Driscol (2012) [17] 1 1 1 0 0 0 0 1 0 1 1 6/11 Good
Fuller et al. (2018) [16] 1 1 0 1 1 0 0 1 1 1 1 8/11 Good
Cheng et al. (2018) [25] 1 0 1 1 0 0 0 1 1 1 1 7/11 Good
Fu et al. (2015) [22] 1 0 0 1 0 0 0 1 1 1 1 6/11 Good
Di Nardo et al. (2015) [21] 1 1 1 1 1 0 0 1 1 1 0 8/11 Good
Yucel et al. (2009) [23] 1 1 0 1 1 0 0 1 0 1 1 7/11 Good

Scale of item score: 0=absent; 1=present. The Physiotherapy Evidence Database (PEDro) scale criteria were (1) specific eligibility criteria; (2) random allocation; (3) concealed allocation; (4) similarity at baseline on key measures; (5) subject blinding; (6) therapist blinding; (7) assessor blinding; (8) >85% follow-up of at least 1 key outcome; (9) intention to treat analysis; (10) between-group statistical comparison for at least 1 key outcome; and (11) point estimates (size of treatment effect) and measures of variability provided for at least 1 key outcome. Studies scoring 9–10 on the PEDro scale were considered to be of “excellent” quality methodologically. Scores ranging from 6 to 8 were of “good” quality while studies scoring 4 or 5 were of “fair” quality, and studies scoring below 4 were considered “poor” quality.


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